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Grignard 시약은 ‘R–Mg–X’ 구조의 유기 마그네슘 할라이드 형태로, 화학자 Victor Grignard의 이름에서 유래했습니다. 매우 높은 반응성을 가져 대부분의 유기 화합물뿐 아니라 물·이산화탄소·산소와도 쉽게 반응합니다.
이 시약은 금속 마그네슘과 알킬 할라이드를 에터(ether) 용매에서 반응시켜 제조되며, 사용되는 할로겐은 주로 염소, 브로민 또는 요오드입니다.
또한, 에틸렌 옥사이드와의 반응을 통해 원래 알킬 할라이드 대비 탄소 수가 두 개 더 많은 알코올을 합성할 수 있습니다. 특히, Grignard 시약의 가장 중요한 용도는 알데하이드 및 케톤과 반응하여 알코올을 생성하는 반응입니다.
*Thermo Fisher Scientific은 다양한 형식의 Grignard 시약 및 관련 제품을 제공하며, 맞춤형 및 벌크 생산 옵션도 지원합니다.
<제품 주요 특성>
- 고반응성 유기 마그네슘(Organomagnesium) 화합물 구조(R–Mg–X)
- 에테르(Ether) 기반 용매와의 높은 호환성
- 알데하이드 (Aldehyde) 및 케톤(Ketone) 과의 선택적 반응을 통한 알코올 합성
- 수분 및 산소에 민감 → 엄격한 품질 관리 필요
<Grignard 반응에 사용 가능한 Thermo Scientific 제품 살펴보기>
| SKU | Name | CAS No. | Size |
| 43886 | (1,3-Dioxolan-2-ylmethyl)magnesium bromide, 0.5M solution in THF, AcroSeal® | 180675-22-3 | 100ml, 800ml |
| 37746 | (Trimethylsilyl)methylmagnesium chloride, 1.3M solution in THF, AcroSeal® | 13170-43-9 | 100ml, 800ml |
| 43169 | [4-(1-Piperidinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal® | 480424-83-7 | 50ml |
| 43177 | [4-(4-Morpholinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal® | 480424-75-7 | 50ml |
| 43467 | 1-Propenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 14092-04-7 | 100ml, 800ml |
| 42607 | 1-Propynylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 16466-97-0 | 100ml, 800ml |
| H54138 | 2,6-Dimethylphenylmagnesium bromide, 0.5M in 2-MeTHF | 21450-64-6 | 100ml |
| 21073 | 2-Mesitylmagnesium bromide, 1M solution in THF, AcroSeal® | 2633-66-1 | 100ml |
| 43556 | 2-Methyl-1-propenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 38614-36-7 | 100ml, 800ml |
| 43875 | 2-Methyl-2-phenylpropylmagnesium chloride, 0.5M solution in diethyl ether, AcroSeal® | 35293-35-7 | 100ml |
| 43174 | 2-Naphthylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 21473-01-8 | 50ml |
| 43461 | 2-Thienylmagnesium bromide, 1M solution in THF, AcroSeal® | 5713-61-1 | 50ml |
| H54654 | 3,4-Dimethoxyphenylmagnesium bromide, 0.5M in THF | 89980-69-8 | 100ml |
| 39215 | 3,5-Bis(trifluoromethyl)phenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 112981-69-8 | 100ml |
| 43194 | 3,5-Dimethylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 34696-73-6 | 50ml |
| 42746 | 3-Butenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 7103-09-5 | 100ml, 800ml |
| H51161 | 3-Chlorophenylmagnesium bromide, 1M in MeTHF | 36229-42-2 | 50ml, 100ml |
| 42782 | 3-Fluorophenylmagnesium bromide, 1M solution in THF, AcroSeal® | 17318-03-5 | 100ml |
| 42675 | 3-Methoxyphenylmagnesium bromide, 1M solution in THF/toluene, AcroSeal® | 36282-40-3 | 100ml |
| H54115 | 4-(2-Tetrahydropyranyloxy)phenylmagnesium bromide, 0.5M in 2-MeTHF | 36637-44-2 | 100ml |
| 45061 | 4-(N,N-Dimethyl)aniline magnesium bromide, 0.5M solution in THF, AcroSeal® | 7353-91-5 | 50ml |
| 43622 | 4-Benzyloxyphenylmagnesium bromide, 0.8M solution in THF, AcroSeal® | 120186-59-6 | 100ml |
| 43162 | 4-Biphenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 3315-91-1 | 100ml |
| 43184 | 4-Fluoro-2-methylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 30897-90-6 | 50ml |
| 37737 | 4-Fluorophenylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® | 352-13-6 | 100ml, 800ml |
| 43163 | 4-Isopropylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 18620-03-6 | 50ml |
| H54078 | 4-Methoxybenzylmagnesium chloride, 0.25M in 2-MeTHF | 38769-92-5 | 100ml |
| 37742 | 4-Methoxyphenylmagnesium bromide, 1M solution in THF, AcroSeal® | 13139-86-1 | 100ml, 800ml |
| H54284 | 4-tert-Butylphenylmagnesium bromide, 0.50 M in 2-MeTHF | 63488-10-8 | 100ml |
| 43286 | 4-tert-Butylphenylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® | 63488-10-8 | 100ml |
| 43173 | 9-Phenanthrylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 71112-64-6 | 50ml |
| 20953 | Allylmagnesium bromide, 1M solution in diethyl ether, AcroSeal® | 1730-25-2 | 100ml, 800ml |
| 20967 | Allylmagnesium chloride, 1.7M solution in THF, AcroSeal® | 2622-05-1 | 100ml, 800ml |
| H51170 | Allylmagnesium chloride, 1M in MeTHF | 2622-05-1 | 100ml, 500ml |
| 036591 | Aluminum magnesium isopropoxide, 99.9% (metals basis), 10% w/v in isopropanol | 69207-83-6 | 25ml, 100ml |
| 38955 | Benzylmagnesium chloride, 1.4M solution in THF, AcroSeal® | 6921-34-2 | 100ml |
| H51165 | Cyclohexylmagnesium chloride, 1M in MeTHF | 931-51-1 | 100ml, 500ml |
| 43361 | Cyclohexylmethylmagnesium bromide, 0.2-0.3M solution in THF, AcroSeal® | 35166-78-0 | 100ml |
| 42745 | Cyclopentylmagnesium bromide, 2.0M solution in diethyl ether, AcroSeal® | 33240-34-5 | 100ml, 800ml |
| 20846 | Cyclopentylmagnesium chloride, 2M solution in diethyl ether, AcroSeal® | 32916-51-1 | 100ml, 800ml |
| H51158 | Cyclopropylmagnesium bromide, 0.5M in MeTHF | 23719-80-4 | 50ml, 100ml |
| 44595 | Cyclopropylmagnesium bromide, 0.5M solution in 2-MeTHF, AcroSeal® | 23719-80-4 | 100ml, 800ml |
| 39761 | Cyclopropylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 23719-80-4 | 100ml |
| 37777 | Di-n-butylmagnesium, 0.5M solution in heptane, AcroSeal® | 1191-47-5 | 100ml, 800ml |
| 45794 | Ethylenediaminetetraacetic acid dipotassium magnesium salt d | 15708-48-2 | 100g, 500g |
| 21047 | ETHYLMAGNESIUM BROMIDE, 0.9M SOLUTION IN THF, ACROSEAL(R) | 925-90-6 | 100ml, 800ml |
| 34729 | Ethylmagnesium bromide, 3M in diethyl ether, AcroSeal® | 925-90-6 | 100ml, 800ml |
| 087291 | Ethylmagnesium bromide, 3M in ether | 925-90-6 | 0.5mole, 1mole |
| 041675 | Ethylmagnesium bromide, 3M in ether, packaged under Argon in resealable ChemSeal^t bottles | 925-90-6 | 0.5mole, 1mole |
| 18353 | Ethylmagnesium bromide, ca. 3.2M solution in 2-MeTHF; AcroSeal® | 925-90-6 | 100ml, 800ml |
| 43912 | Ethynylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 4301-14-8 | 100ml, 800ml |
| 38895 | Ethynylmagnesium chloride, 0.5M solution in THF/Toluene, AcroSeal® | 65032-27-1 | 100ml, 800ml |
| 43303 | Heptylmagnesium bromide, 1M solution in diethyl ether, AcroSeal® | 13125-66-1 | 100ml |
| 42776 | Hexylmagnesium bromide, 0.8M solution in THF, AcroSeal® | 3761-92-0 | 100ml, 800ml |
| 43468 | Hexylmagnesium chloride, 2M solution in THF, AcroSeal® | 44767-62-6 | 100ml, 800ml |
| 42739 | Isobutylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® | 926-62-5 | 100ml, 800ml |
| 20952 | Isobutylmagnesium chloride, 2M solution in diethyl ether, AcroSeal® | 5674-02-2 | 100ml |
| 42775 | Isopropenylmagnesium bromide, 0.5M solution in THF, AcroSeal® | 13291-18-4 | 100ml, 800ml |
| H54840 | Isopropylmagnesium bromide, 3M in 2-MeTHF | 920-39-8 | 100ml |
| 42678 | Isopropylmagnesium bromide, 3M solution in 2-MeTHF, AcroSeal® | 920-39-8 | 100ml |
| 38628 | Isopropylmagnesium chloride - Lithium chloride complex, 1.3M solution in THF, AcroSeal® | 745038-86-2 | 100ml, 800ml |
| 21285 | Isopropylmagnesium chloride, 2.0M solution in THF, AcroSeal® | 1068-55-9 | 100ml, 800ml |
| 44600 | Methylmagnesium bromide, 1M solution in CPME, AcroSeal® | 75-16-1 | 100ml, 800ml |
| 37738 | Methylmagnesium bromide, 1M to 1.5M solution in THF, AcroSeal® | 75-16-1 | 100ml, 800ml |
| 39112 | Methylmagnesium bromide, 3.2M solution in 2-MeTHF, AcroSeal® | 75-16-1 | 100ml, 800ml |
| 18354 | Methylmagnesium bromide, 3M solution in diethyl ether, AcroSeal® | 75-16-1 | 100ml, 800ml |
| 25256 | Methylmagnesium chloride, 3M (22 wt.%) solution in THF, AcroSeal® | 676-58-4 | 100ml, 800ml |
| 42740 | Methylmagnesium iodide, 3M solution in diethyl ether, AcroSeal® | 917-64-6 | 100ml, 800ml |
| 38118 | n-Butylethylmagnesium, 0.9M solution in heptane, AcroSeal® | 62202-86-2 | 100ml, 800ml |
| H51162 | n-Propylmagnesium chloride, 1M in MeTHF | 2234-82-4 | 100ml, 500ml |
| 42781 | Octylmagnesium bromide, 2M solution in diethyl ether,AcroSeal® | 17049-49-9 | 100ml, 800ml |
| 42803 | Octylmagnesium chloride, 1.4M solution in THF, AcroSeal® | 38841-98-4 | 100ml, 800ml |
| 42747 | o-Tolylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® | 932-31-0 | 100ml |
| 43874 | Pentafluorophenylmagnesium bromide, 0.5M solution in diethyl ether, AcroSeal® | 879-05-0 | 100ml |
| 43555 | Pentylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® | 693-25-4 | 100ml, 800ml |
| 42780 | Phenethylmagnesium chloride, 1M solution in THF, AcroSeal® | 90878-19-6 | 100ml, 800ml |
| 44596 | Phenylmagnesium bromide, 1.6M solution in CPME, AcroSeal® | 100-58-3 | 100ml, 800ml |
| 087326 | Phenylmagnesium bromide, 3M in ether | 100-58-3 | 100ml, 500ml |
| 42676 | p-Tolylmagnesium bromide, approx. 0.5M solution in diethyl ether, AcroSeal® | 4294-57-9 | 100ml, 800ml |
| 39430 | tert-Butylmagnesium chloride, 1.7M solution in diethyl ether, AcroSeal® | 677-22-5 | 100ml, 800ml |
| 33167 | tert-Butylmagnesium chloride, 1.7M solution in THF, AcroSeal® | 677-22-5 | 100ml, 800ml |
| H51164 | tert-Butylmagnesium chloride, 1M in MeTHF | 677-22-5 | 100ml, 500ml |
| 20939 | Vinylmagnesium bromide, 0.7M solution in THF, AcroSeal® | 1826-67-1 | 100ml, 800ml |
| 44597 | Vinylmagnesium bromide, 1M solution in 2-MeTHF, AcroSeal® | 1826-67-1 | 100ml, 800ml |
| 25259 | Vinylmagnesium chloride, 1.5M (13 wt.%) solution in THF, AcroSeal® | 3536-96-7 | 100ml, 800ml |
<대표 키워드>
Grignard reagent, Organomagnesium, R–Mg–X, C–C bond formation, Alcohol synthesis, Carbonyl reaction, Organometallic reagents